SERGEY I. Chernysh

Professor Sergey I. Chernysh was a world-renowned expert in the area of immune systems of insects, and a member of the Russian Academy of Natural Sciences. Professor Chernysh held a PhD degree from the St. Petersburg State university (Doctor of biological sciences), and he was an active Professor in the State University of St. Petersburg, Russia, a scientific vice-director of the Biological Institute of St. Petersburg State University and a head of the Entomology laboratory of St. Petersburg State University.

Education

  • Petersburg State University, Faculty of Biology (1969-1974)
  • Scientific degrees: PhD (1977) in St. Petersburg State University; DS (Doctor of biological science) (1990)
  • Honorary title: full member of Russian Academy of Natural Science

Professional career

  • 1974-1987 – researcher and senior researcher in the Entomology laboratory of St. Petersburg State University
  • 1987-1991 – scientific vice-director of Biological Institute of St. Petersburg State University
  • Since 1991 – Head of Entomology laboratory of St. Petersburg State University
  • Since 2007 – Head of Insect Biopharmacology and Immunology laboratory of St. Petersburg State University
  • Since 2004 – founder and president of Allopharm Co

Main inventions

  • Alloferons (Patents RU 2172322; US7462360B2; EP1114829B1)
  • Allostatines (Patents RU 2 267 496; US 8,372,406 B2; EP 1 705 182)
  • FLIP7 (RU 2 447 896; WO/2018/226119)

Main publications

  • Chernysh SI, Gordya NA, Tulin DV, Yakovlev AYu Biofilm infections between Scylla and Charybdis: interplay of host antimicrobial peptides and antibiotics. Infection and Drug Resistance 2018:11 501–514
  • Gordya N, Yakovlev A, Kruglikova A, Tulin D,, Potolitsina E, Suborova T, Bordo D, Rosano C,  Chernysh S Natural antimicrobial peptide complexes in the fighting of antibiotic resistant biofilms: Calliphora vicina medicinal maggots PLoS ONE 2017, 12(3): e0173559.doi:10.1371/journal.pone.0173559
  • Gordya NA, А. P. Nesin, N. P. Simonenko, and S. I. Chernysh Regulation of Antimicrobial Peptide Synthesis in Larvae of Calliphora vicina (Diptera, Calliphoridae): a Dose-Dependent Effect of Ecdysteroids Journal of Evolutionary Biochemistry and Physiology, 2016, Vol. 52, No. 4, pp. 292—298
  • Chernysh S., Gordya N., Suborova T. Insect Antimicrobial Peptide Complexes Prevent Resistance Development in Bacteria. PLOS ONE, 2015 DOI:10.1371/journal.pone.0130788 July 15, 2015
  • Chernysh S., Kozuharova I. Anti-tumor activity of a peptide combining patterns of insect alloferons and mammalian immunoglobulins in naïve and tumor antigen vaccinated mice, Intern. Immunopharmacology, 2013, 17: 1090-1093
  • Chernysh S. Anti-tumor Activity of Hybrid Peptides Combining Structure of Insect and Human Immunologicals International Congress Drug Discovery Science and Technology, November 8-10, Najing, China, 2012, p. 21
  • Chernysh S, Kozuharova I, Artsibasheva I. Anti-tumor activity of immunomodulatory peptide alloferon-1 in mouse tumor transplantation model, Intern Immunopharmacol 2012; 12: 312-314
  • Kruglikova A.A., Chernysh S.I. Antimicrobial compounds from the excretions of surgical maggots, Lucilia sericata (Meigen) (Diptera, Calliphoridae) Entomological Review, 2011, 91, 7, 813-819
  • Chernysh SI, Gordja NA. The immune system of maggots of the blow fly (Calliphora vicina) as a source of medicinal drugs. J Evol Biochem Physiol. 2011; 47(6):524-533
  • Myung-Jeom Ryu, Vadim Anikin, Seok-Ho Hong, Hyesung Jeon, Yeon Gyu Yu, Myeong-HeeYu, Sergey Chernysh, Cheolju Lee. Activation of NF-kB by alloferon through down-regulation of antioxidant proteins and IkBα, Mol. Cell Biochem, 2008, 313, p. 91-102
  • Chernysh S.I., N.A. Filatova, N.S.Chernysh. Cytotoxic activity of blow fly Calliphora vicina hemocytes. Journal of Insect Physiology, 2004, v. 50 pp 777-781
  • Chernysh S.I., S.I. Kim, G. Bekker, V.A. Pleskach, N.A. Filatova, V.B. Anikin, V.G. Platonov and Philippe Bulet. Antiviral and antitumor peptides from insects. PNAS, 2002, vol. 99 , n. 20, p. 12628-12632
  • Chernysh S. I, Gordja N. A, Simonenko N. P.Diapause and Immune Response: Induction of Antimicrobial Peptides Synthesis in the Blowfly, Calliphora vicina R.-D. (Diptera, Calliphoridae). Entomological science, 2000, v. 3, No 1, p. 139-144
  • Chernysh S.I.,Simonenko N.P., Braun A., Meister M. Developmental variability of the antibacterial response in larvae and pupae of Calliphora vicina (Diptera, Calliphoridae) and Drosophila melanogaster(Diptera, Drosophilidae) Eur. J. of Entomol.,1995, 93, p.203-209
  • Chernysh S.I. Neuroendocrine system in insect stress In: Hormones and metabolism in insect stress, CRC Press, Boca Raton, 1990, p. 68-97 (USA)