Anti-Tumor & Anti-Viral Properties

Structure
ALLOSTATIN® is a lyophilized peptide that has a structural similarity to insect Alloferon and mammalian immunoglobulins.

Production Method
Allostatin® is obtained through chemical synthesis.

Applications
It is used in preparations with antiviral and antitumor activity and skin care products. In addition, Allostatin is very effective in prevention and suppression of cytokine-storm.

Clinical Studies
Allostatin has undergone preclinical trials and is currently under clinical evaluation for entering a clinical trial as a cancer drug and as an antiviral agent.

Patents
Patent of the Russian Federation No. 2267496

Anti-Tumor & Anti-Viral Solutions

The Problem Of Cancer

Cancer in China

  • Since 2010, cancer is the leading cause of death in China and is a major public health problem.

Cancer in China

  • Since 2010, cancer is the leading cause of death in China and is a major public health problem.
  • Close to 4.3 million new cancer cases and 2.81 million cancer deaths were reported in 2015, with lung cancer being the most common incident cancer and the leading cause of cancer death.

The Real Problem Of Cancer

  • The real problem with cancer is – no visibility. In other words, the immune system is not being able to recognize cancer cells in order to attack them. The only exception is when cancer cells lose the HLA expression (which is quite rate).
  • The only drugs in existence that is global in scope and is able to treat all types of cancers are chemo-therapy drugs.  Chemo drugs are efficient against all types of cancer, however they are unable to detect and kill cancer cells selectively. Instead, they attack and kill all young cells in the human body. As a result, patients treated with chemo therapy experience severe side effects.
  • The modern medicine has made significant advances in cancer treatments. Immuno-therapy (such as CAR-T, CAR-NK) are very effective in treatment of cancers that express a single antigen. However, most of the cancers express multiple antigens, and cannot be treated efficiently.

The Solution

Global, effective, low cost (15 USD) cancer treatment for all types of cancer with no side effects. Effective Alternative for Chemotherapy.

  • Allostatine is a synthetic immunomodulatory peptide for cancer and viral infections immunotherapy and cell therapy.
  • A selective activator of cytotoxic cells in the human immune system. In the presence of Allostatine, natural killer (NK) cells more efficiently recognize and lyse tumor cells and virus-infected cells.
  • Effective in both Prevention and treatment of cancers.
  • Allostatine is more effective than chemo drugs, it is easily administered through a subcutaneous injection within minutes, there are no side effects, and can easily be combined with any other treatment.
  • The total cost of Allostatine cycle (2 injections, similar to a chemo cycle) is estimated to 30 USD. Cost of one cycle of chemotherapy is typically calculated in thousands of dollars.
  • The drug is ready to enter a clinical trial.

Mode Of Action

  • Allostatine is a new type of immunomodulator that enables immune system (NK cells) to recognize cancer and virus cells (even if they have not lost HLA expression) and immediately attack them.
  • The essence of this new approach is to “train” the patient’s immunity to recognize weak tumor antigens.
  • The method of action is global (not antigen based), which means that Allostatine is effective against all types of cancer.
  • Allostatine is selective, only cancer and viral cells are being attacked by the immune system in presence of Allostatine.
  • A safety study of Allostatine showed a complete absence of toxicity.

Allostatine R&D Program

Allostatine topical (herpes, papillomas, warts)

A topical formulation of Allostatine has already been developed and is currently available as a cosmetic solution. It has shown high clinical efficacy in various viral infections of the skin and mucous membranes (herpes simplex virus, Epstein-Barr, cytomegalovirus, human papilloma). Each of these socially significant infections makes up a large section of dermatology and urogynecology.

The Allostatine topical product has a promise to become a gold standard in treatments of herpes, papillomas and warts and will enter a clinical trial by end of 2020.

Allostatine injectable for cancer

The Allostatine injectable drug is a promising new drug with systemic action for treatments of all types of cancer and many viral infections. The presence of this drug in the patient’s body activates the immune system and enables NK cells to recognize cancer and viral cells and attack them. The method of action is selective, there are no side effects and there are no damage to healthy cells.

Allostatine is highly efficient against all types of cancer, it is selective (only cancer and viral cells are destroyed), there are no known side effects, and will be sold at low cost (15 USD per injection, where 2 injections can replace a chemo cycle). Due to these advantages, it could be widely used and be high in demand replacement drug for a chemotherapy.

Allostatine injectable for Virus infections

The key link in virus strategy is the inhibition of the activity of NK cells through complex manipulation of the surface receptors of an infected cells. The problem of recognition of weak antigens is also a key in treatment of chronic (persistent) viral infections.

Allostatine has already shown clinical efficacy in both prevention and treatment of chronic (persistent) viral infections such as herpes, HPV, hepatitis C, HIV (the new Corona virus is under investigation).

Cold Sores

Clinically Proven Efficacy and Gold Standard in treatment of Cold Sores (labial herpes)

Cold sores (labial herpes) is the most ubiquitous skin disorder (over 50 million patients in USA only)

Cervical Viral Infections

Clinically Proven Efficacy and Gold Standard in treatment of Cervical Viral Infections

  • Cervical HPV infections cause cervical cancer
  • Cervical CMV and EBV are major causes of newborn pathologies
  • HPV, CMV and EBV infections prevail in the most humans but have no effective drugs so far

Sarcoma Treatment

Clinically Proven Efficacy and Gold Standard in treatment of Cervical Viral Infections

A pre-clinical study was carried out to determine the efficacy of Allostatine in prevention and treatment of Sarcoma. Sarcoma cancer cells was transplanted in all mice that was subject to the study. The results, after 20 days of the study were as follows:

  • 100% of all mice that did not receive any treatment developed cancer and died (See the picture above)
  • 73% of all mice treated with a cancer vaccine (developed in Nederland) developed carcinoma and died. (Since Sarcoma expresses multiple antigens, cancer vaccine is considered to be most effective treatment method for Sarcoma).
  • Only 5% of the mice treated with a combination of Cancer Vaccine and Allostatine developed Sarcoma. The survival rate in this group was 95%.

Lungs Cancer

Lungs Cancer is the number 1 cancer in the world

Non Small Cell Lungs Cancer Cells

Cancer Cells + Immune Cells

Cancer Cells + Immune Cells + Allostatine

Cervical Cancer

Cervical cancer is the number 2 cancer in woman in the world

Propidium iodide staining

Flow Cytometry Report, % of fatally damaged cervical cancer cells

Chemo vs Allostatin

Allostatin can be considered as an alternative to Chemotherapy, or can be combined with Chemotherapy to improve the efficacy of the chemotherapy treatment

Allostatine can be considered as an alternative to Chemo Therapy

Allostatine Summary

1. Allostatine Topical (medical device)
This medical device has already demonstrated high success rate and gold standard in treatment of viral infections such as Cervical HPV infection (causes cervical cancer), Cervical CMV and EBV (major cause of pathologies in newborns). HPV, CMV and EBV infections prevail in most humans but there are no effective drugs so far.

Expected on the markets: China (2022), other markets (2020)

2. Allostatine injectable
The Allostatine injectable drug is a promising new drug with systemic action for treatments of all types of cancer and many viral infections.

This drug is unique in its ability to detect cells infected by virus and activate the immune system to destroy them. It can be used effectively in both prevention and treatment of many viruses, including a possibility for prevention and treatment of Corona Viruses.

In cancer treatment, this drug is effective against all types of cancers. Due to its efficacy, no side effects, and low cost, this drug has a potential to efficiently replace the chemo therapy as a first line in cancer treatments.